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castor oil  (MedChemExpress)


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    Structured Review

    MedChemExpress castor oil
    Castor Oil, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/castor oil/product/MedChemExpress
    Average 93 stars, based on 12 article reviews
    castor oil - by Bioz Stars, 2026-02
    93/100 stars

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    JB restores mitophagy and improves cognitive decline in 5×FAD AD mice. A , electron microscopy images showing the effects of JB on mitochondrial morphology and mitophagy-like events in mouse hippocampal brain tissues. B , representative swimming tracks of mice on day 5 in the Morris water maze test. C , latency to reach the platform from day 1 to day 7 (n = 9 per group; mean ± s.e.m.; two-way ANOVA; ∗ p < 0.0332, ∗∗ p < 0.0021). D – E , swimming time and distance in the target quadrant on day 5. F , number of platform crossings on day 5. G , spontaneous alternation rate in Y-maze test. H – J , recognition index for time, entries and distance traveled around the novel object in the short-term novel object recognition test. K – M , open field test results: number of central zone entries, time spent in the central zone, and vertical count. n = 9 mice per group. Data are shown as mean ± s.e.m. Statistical significance was determined using one-way ANOVA. ∗ p < 0.0332, ∗∗ p < 0.0021, ∗∗∗ p < 0.0002, ∗∗∗∗ p < 0.0001. AD, Alzheimer's disease; JB, jolkinolide B.

    Journal: Molecular & Cellular Proteomics : MCP

    Article Title: Jolkinolide B Activates Mitophagy to Exhibit Antipancreatic Cancer Activity and Alleviate Cognitive Deficits in Alzheimer's Disease

    doi: 10.1016/j.mcpro.2025.101060

    Figure Lengend Snippet: JB restores mitophagy and improves cognitive decline in 5×FAD AD mice. A , electron microscopy images showing the effects of JB on mitochondrial morphology and mitophagy-like events in mouse hippocampal brain tissues. B , representative swimming tracks of mice on day 5 in the Morris water maze test. C , latency to reach the platform from day 1 to day 7 (n = 9 per group; mean ± s.e.m.; two-way ANOVA; ∗ p < 0.0332, ∗∗ p < 0.0021). D – E , swimming time and distance in the target quadrant on day 5. F , number of platform crossings on day 5. G , spontaneous alternation rate in Y-maze test. H – J , recognition index for time, entries and distance traveled around the novel object in the short-term novel object recognition test. K – M , open field test results: number of central zone entries, time spent in the central zone, and vertical count. n = 9 mice per group. Data are shown as mean ± s.e.m. Statistical significance was determined using one-way ANOVA. ∗ p < 0.0332, ∗∗ p < 0.0021, ∗∗∗ p < 0.0002, ∗∗∗∗ p < 0.0001. AD, Alzheimer's disease; JB, jolkinolide B.

    Article Snippet: At 3 months of age, 5×FAD AD mice were randomized into two groups: one treated with JB (60 mg/kg/day, dissolved in PBS containing 15% castor oil; castor oil, MedChemExpress, HY-107799) and the other with vehicle control (PBS containing 15% castor oil), while WT mice received the same vehicle (PBS containing 15% castor oil) as blank controls.

    Techniques: Electron Microscopy